Brian Cox may refer to:

• Brian Cox (actor) (born 1946), Scottish actor
• Brian Cox (physicist) (born 1968), English physicist, broadcaster and former keyboard player
• Brian Cox (director), American film director
• Brian Cox (footballer) (born 1961), English goalkeeper
• Brian Cox (poet) (1928–2008), English scholar, editor of Critical Quarterly and author of the Black Papers
• Brian Cox (American football), American football coach
• Bryan Cox (born 1968), American football coach and former player
• Bryan Cox Jr. (born 1994), American football defensive end
• Bryan-Michael Cox (born 1977), American songwriter and record producer