Domini Blythe (August 28, 1947 – December 15, 2010) was a British-born Canadian actress. Her numerous stage, film and television credits included Search for Tomorrow, External Affairs, Savage Messiah, Montreal Stories and Mount Royal.

Blythe graduated from the Central School of Speech and Drama in London. She worked for the Royal Shakespeare Company and made her stage debut in London's West End in 1970 in Oh, Calcutta!. She appeared as Anna Müller in the Hammer film Vampire Circus in 1972 before moving to Canada the same year, eventually settling in Stratford, Ontario. She went on to perform in many leading roles at the Stratford Shakespeare Festival and the Shaw Festival in Niagara-on-the-Lake.

Blythe died of cancer in Montreal on December 15, 2010, at the age of 63. She was survived by her husband, Jean Beaudin; father, Richard Blythe; and brother, Ben Blythe.

Some sources identified film writer-director Jean Beaudin as her husband. The London Independent reported that he was "her partner of more than 20 years".