Matthew Deane may refer to:

• Sir Matthew Deane, 1st Baronet (c. 1626–1711) of the Deane Baronets
• Sir Matthew Deane, 3rd Baronet (c. 1680–1747), Irish MP for Charleville and Cork County
• Sir Matthew Deane, 4th Baronet (c. 1706–1751), his son, Irish MP for Cork City
• Matthew Deane (actor) (born 1984), Australian actor