Matthew Lewis may refer to:

• Matthew Lewis (writer) (1775–1818), British Gothic novelist and dramatist
• Matthew Lewis (actor) (born 1989), English actor, most famously portraying Neville Longbottom in the Harry Potter films
• Matthew Butler (Tiswas) (born 1974), British child performer who appeared on Tiswas, now known as Matthew Lewis
• Matthew Jay Lewis, British actor
• Matt K. Lewis, American political blogger, commentator, and senior contributor to The Daily Caller
• Matthew Lewis (footballer) (born 1990), Australian association football (soccer) player for A-League side Central Coast Mariners
• Matt Lewis (soccer) (born 1996), American soccer player
• Matty Lewis (born 1975), American singer and co-frontman of the Rock band Zebrahead
• Matthew Lewis (photographer), American photographer and editor
• Matthew Lewis (water polo) (born 1994), New Zealand water polo player
• Matt Lewis (wheelchair rugby) (born 1987), Australian wheelchair rugby player