Meredith Henderson (born November 24, 1983) is a Canadian actress best known for playing the title role in The Adventures of Shirley Holmes.

She also had a leading role as wheelchair-using Cleo Bellows in the 2001 children's television series MythQuest opposite Christopher Jacot.

In 2005, she appeared in Shania: A Life in Eight Albums, a biopic of country star Shania Twain, in which she played the lead role. She did all the singing, dancing and guitar playing herself.

Henderson also had a recurring role as the girlfriend of Harris Allan's character Hunter on the critically acclaimed, groundbreaking gay TV series Queer as Folk.