Nicholas Smith may refer to:

• Nicholas Smith (actor) (1934–2015), English television actor
• Nicholas Smith (cricketer) (born 1946), New Zealand cricketer
• Nick Smith (footballer, born 1984), Australian rules football player for Melbourne
• Nick Smith (footballer, born 1988), Australian rules football player for the Sydney Swans
• Nicholas G. Smith (1881–1945), American leader in The Church of Jesus Christ of Latter-day Saints
• Nicholas Smith (MP), English politician
• Nicholas M. Smith Jr. (1914–2003), nuclear physicist and research consultant
• Nicholas Smith (Illinois politician), member of the Illinois House of Representatives
• Nicholas Hankey Smith (1771–1837), British diplomat