Shirley Cain (born 30 April 1935 in the West Midlands, England) is a British television actress.

Her television appearances include:

• Murder Must Advertise (1973)
• Upstairs Downstairs (Wanted – a Good Home and Laugh a Little Louder Please, (1975)
• Malice Aforethought (1979)
• Pride and Prejudice (1980)
• Dombey and Son (1983)
• The Pickwick Papers (1985)
• Harem (1986)
• The Bill (Long Odds (1984)
• Strong Poison (1987)
• The Bill, Duplicates (1988))
• The Darling Buds of May (The Darling Buds of May: Part 2 and When the Green Woods Laugh: Part 1, 1991).

Her only feature film appearance was in Villain (1971).